Antihypertensive (combination of Angiotensin II Receptor Blocker and Thiazide Diuretic)
Brand of Irbesartan; Hydrochlorothiazide
Last reviewed April 2026
NAFDAC registration currently inactive
This product's NAFDAC registration is not currently active. It may still be available in pharmacies, but you should verify its status with your pharmacist before use.
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This is a combination tablet containing two medicines — Irbesartan (which relaxes blood vessels) and Hydrochlorothiazide (a water tablet that helps your body remove extra salt and water through urine). Together, they work to lower high blood pressure more effectively than either one alone.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Take one tablet once a day, usually in the morning. You can take it with or without food, but try to take it at the same time every day. Swallow the tablet whole with a glass of water. Your doctor will decide whether you need the 150/12.5 mg or 300/12.5 mg strength.
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue as normal. Do not take two tablets at the same time to make up for a missed dose.
Only buy this medicine from a licensed pharmacy — do not buy from roadside sellers or open markets, as fake blood pressure drugs are common in Nigeria. Do not stop taking this medicine on your own even if you feel fine, because high blood pressure often has no symptoms but can cause stroke or heart attack. Drink enough water daily, especially during hot weather, but follow your doctor's advice on fluid intake.
Avoid taking this medicine with potassium supplements or potassium-sparing water tablets, as it can cause dangerous changes in your potassium levels. Be careful with painkillers like ibuprofen and diclofenac (very common in Nigeria), as they can reduce the blood pressure-lowering effect and harm your kidneys. Alcohol can make the dizziness and blood pressure drop worse, so limit or avoid it.
Check your specific combination
Is it safe to take Irbesartan; with your other drugs?
This medicine is NOT safe during pregnancy — it can seriously harm or even kill your unborn baby, especially in the second and third trimesters. It is also not recommended during breastfeeding. Tell your doctor immediately if you become pregnant.
Store in a cool, dry place below 30°C — away from direct sunlight and humidity, which is very important in Nigeria's hot weather. Keep it in its original pack and away from children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Genuine packaging for Co-Aprovel 300 mg/25 mg Tablets
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NAFDAC Number
B4-2317
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