Antiretroviral (HIV medicine: combination of an integrase inhibitor, a nucleoside reverse transcriptase inhibitor, and a nucleotide reverse transcriptase inhibitor)
Last reviewed July 2026
Who is this for?
This is a combination tablet containing three antiretroviral (anti-HIV) medicines: Dolutegravir, Lamivudine, and Tenofovir Alafenamide, which work together to stop HIV from multiplying in your body, helping your immune system stay strong.
Inhibits HIV replication through three complementary mechanisms: dolutegravir blocks HIV integrase to prevent viral DNA integration into the host genome; lamivudine and tenofovir alafenamide inhibit reverse transcriptase to prevent conversion of viral RNA to DNA. Together, these agents suppress viral replication at multiple stages of the HIV life cycle.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you remember within 12 hours of your usual time, take it immediately. If it is almost time for your next dose, skip the missed one and continue your normal schedule. Never take two tablets at once to make up for a missed dose.
Always collect your ARV refills on time from approved government or accredited private facilities; do not buy from roadside vendors or unverified sources, as fake HIV drugs are dangerous. Never share your ARV medication with anyone, even if they are also HIV positive, because dosing and drug combinations differ. This medicine does not cure HIV, so you must take it every single day for life to keep the virus under control and stay healthy.
Avoid taking this drug at the same time as antacids, calcium, or iron supplements; take them at least 2 hours apart or 6 hours after, as they reduce how well the medicine works. Rifampicin (commonly used for TB treatment in Nigeria) can reduce the effectiveness of Dolutegravir, so your doctor may need to adjust your dose. Avoid excessive alcohol as it can worsen liver side effects and make it harder to remember your daily dose.
Check your specific combination
Is it safe to take Dolutegravir; with your other drugs?
This combination may be used during pregnancy and breastfeeding under your doctor's guidance, but you must consult your doctor first as they will weigh the benefits and risks for you and your baby.
Store in a cool, dry place below 30°C, away from direct sunlight and humidity. In hot Nigerian weather, keep it inside a cupboard, not near windows or in your car. Always keep it in the original container and far from children's reach.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.