Combination: Strong Corticosteroid, Antifungal, Antibiotic
Last reviewed July 2026
Who is this for?
This is a combination cream that contains three active ingredients: clobetasol (a very strong steroid that reduces swelling, redness, and itching), miconazole (an antifungal that kills fungus), and neomycin (an antibiotic that kills bacteria). It works by tackling skin infections caused by fungus and bacteria while calming inflammation at the same time.
Inhibits fungal ergosterol synthesis via lanosterol 14α-demethylase, suppresses bacterial protein synthesis via 30S ribosomal subunit inhibition, and activates glucocorticoid receptors to reduce inflammatory cytokine production and immune cell infiltration.
Skin infections with itching and rashes, fungal skin infections (ringworm, eczema with infection), bacterial skin infections, mixed skin infections with swelling and redness, jock itch with bacterial infection
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you forget to apply the cream, use it as soon as you remember. If it is almost time for your next application, skip the missed one and continue as normal. Do not apply double the amount to make up for the missed dose.
Important for antibiotics
Always complete the full course even if you feel better. Stopping early can cause the infection to return and become drug-resistant.
Do not use this cream longer than your doctor recommended, as long-term use of strong steroid creams can permanently damage your skin. Buy only from reputable pharmacies and avoid roadside sellers, as fake creams are common in Nigeria. Do not share this cream with others even if they have similar skin problems, as their condition may require a different treatment.
Avoid using other steroid creams or medicated skin products on the same area at the same time, as this can increase side effects. If you are taking blood-thinning medicines like warfarin, let your doctor know as neomycin may affect how they work. Do not mix with other antifungal or antibiotic creams unless your doctor says so.
Check your specific combination
Is it safe to take Clobetasol; with your other drugs?
This cream is not considered safe during pregnancy or breastfeeding. Do not use it without consulting your doctor first, especially on large skin areas or for long periods.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep the tube tightly closed after use. Store out of the reach of children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
Tap a brand for packaging, NAFDAC details and authenticity check
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.