Anti-glaucoma (Carbonic Anhydrase Inhibitor + Alpha-2 Agonist combination)
Last reviewed July 2026
Who is this for?
Brinzolamide/Brimonidine (sold as Simbrinza Eye Drops in Nigeria) is a combination eye drop that works in two ways: one ingredient reduces the amount of fluid your eye produces, while the other helps fluid drain out more easily, both working together to lower pressure inside your eye.
Inhibits carbonic anhydrase enzyme to reduce aqueous humour production while activating alpha-2 adrenergic receptors to increase uveoscleral outflow and decrease aqueous humour formation, thereby reducing intraocular pressure.
High eye pressure (glaucoma), raised pressure in the eye (ocular hypertension)
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you forget a dose, put in the drop as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue with your normal schedule. Do not put in a double dose to make up for it.
Always buy Simbrinza from a licensed pharmacy and do not buy eye drops from roadside sellers or open markets as they may be fake or improperly stored. Do not share your eye drops with anyone else, even if they have similar eye problems. If you wear contact lenses, remove them before putting in the drops and wait at least 15 minutes before putting them back in.
If you are taking blood pressure medicines (like amlodipine or lisinopril), this eye drop can lower your blood pressure further and make you feel dizzy. Avoid drinking alcohol while using this medicine as it can increase drowsiness. Tell your doctor if you are taking any antidepressant medications, as they can interact dangerously with brimonidine.
Check your specific combination
Is it safe to take Brinzolamide; with your other drugs?
This medicine is not recommended during pregnancy or breastfeeding, so consult your eye doctor before using it if you are pregnant, planning to become pregnant, or breastfeeding.
Store at room temperature, away from direct sunlight and heat. Nigerian weather can be very hot, so do not leave it in your car or near a window. Keep the bottle tightly closed when not in use. Keep away from children. Discard the bottle 4 weeks after opening, even if there is medicine left inside.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.