Antihypertensive (Beta-blocker + Diuretic combination)
Last reviewed July 2026
Who is this for?
Atenolol/Chlortalidone is a combination drug that contains two medicines: one (atenolol) slows down your heart and relaxes blood vessels, while the other (chlortalidone) helps your body remove extra water and salt through urine. Together, they work to bring down high blood pressure.
Blocks β1-adrenergic receptors in the heart and vasculature, reducing cardiac output and peripheral vascular resistance, while chlortalidone inhibits sodium reabsorption in the distal convoluted tubule by blocking the Na-Cl cotransporter, promoting natriuresis and reducing blood volume.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take two tablets at once to make up for the missed dose.
Only buy from licensed pharmacies. Tenoret 50 is the known brand in Nigeria, so be suspicious of unusually cheap or unbranded versions from roadside sellers. Do not stop this medicine suddenly on your own, even if you feel fine, as it can cause dangerous spikes in blood pressure or heart problems. Drink enough water daily, but check with your doctor about how much since this drug makes you urinate more.
Avoid taking this drug with other blood pressure medicines without your doctor knowing, as your blood pressure could drop too low. NSAIDs like ibuprofen (commonly sold in Nigeria) can reduce the effectiveness of this drug. Alcohol can increase dizziness and make your blood pressure drop dangerously low, so limit or avoid it.
Check your specific combination
Is it safe to take Atenolol; with your other drugs?
This drug is not safe during pregnancy as it can harm the unborn baby, and it can pass into breast milk. Do not use it if you are pregnant or breastfeeding unless your doctor says it is absolutely necessary.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep it in its original container and always keep away from children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.