Artesunate 50 mg + Amodiaquine 135 mg Tablets

Who is this for?

Artesunate + Amodiaquine is a combination antimalarial drug that contains two medicines working together to kill the malaria parasite in your blood — artesunate kills the parasites quickly while amodiaquine keeps working longer to make sure they don't come back.

Inhibits parasite protein synthesis and DNA replication through multiple mechanisms: artesunate generates reactive oxygen species that damage Plasmodium parasites, while amodiaquine intercalates parasite DNA and inhibits heme polymerization, preventing malaria parasite survival and clearance of blood-stage infection.

Is Artesunate; safe to take with another drug?

For adults (above 36 kg body weight), take 2 tablets of the adult strength (Artesunate 100 mg + Amodiaquine 270 mg) once daily for 3 days. Take it with food or after eating to reduce stomach upset. Complete all 3 days even if you feel better after the first day. Popular brands in Nigeria include Apmod 100/270, Camosunate, and Artesunate-Amodiaquine Winthrop.

If you miss a dose, take it as soon as you remember on the same day. If it is almost time for the next day's dose, skip the missed one and continue with the normal schedule. Do not take two doses at once to make up for it.

• Nausea or vomiting
• loss of appetite
• dizziness or weakness
• stomach pain
• body itching

Avoid taking this drug with efavirenz or zidovudine (HIV medications) as it can increase side effects — tell your doctor if you are on HIV treatment. Do not take with other antimalarials like mefloquine or halofantrine as this can cause dangerous heart rhythm problems. Avoid alcohol during the 3-day treatment as it can worsen dizziness and liver stress.

Store in a cool, dry place away from direct sunlight and heat — avoid storing near windows or in hot cars. Keep in the original packaging and away from moisture. Always keep out of reach of children.