Twynsta 40/10 mg Tablets

Who is this for?

This is a combination medicine containing two blood pressure-lowering drugs — Telmisartan (which relaxes blood vessels by blocking a chemical called angiotensin) and Amlodipine (which relaxes blood vessels by reducing calcium entry into vessel walls). Together, they work in two different ways to bring your blood pressure down more effectively.

Blocks angiotensin II type 1 (AT1) receptors and L-type calcium channels, reducing peripheral vascular resistance and vasodilation to lower blood pressure through dual inhibition of the renin-angiotensin-aldosterone system and calcium-dependent vascular contraction.

Is Amlodipine safe to take with another drug?

Take one tablet once daily, with or without food. Swallow it whole with a glass of water. Try to take it at the same time every day so you don't forget. Your doctor will choose the right strength for you — common Nigerian brands include Cardiotan, Twynsta, Telam, and Telsartam. Do not stop taking it even if you feel fine, because high blood pressure often has no symptoms.

If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take two tablets at once to make up for the missed dose.

• Swelling of the ankles or feet
• dizziness or feeling lightheaded
• headache
• feeling tired or weak
• stuffy nose

Avoid taking with other blood pressure medicines (like ACE inhibitors such as Lisinopril or Ramipril) without your doctor's guidance, as this can cause dangerously low blood pressure. NSAIDs like ibuprofen (commonly used for body pain in Nigeria) can reduce the effectiveness of this drug and affect your kidneys. Alcohol can increase dizziness and lower your blood pressure further, so limit or avoid it.

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it on windowsills or in your car. Keep the tablets in their original pack and away from children.