Antihypertensive (combination of Calcium Channel Blocker and Angiotensin II Receptor Blocker)
Last reviewed July 2026
Who is this for?
This is a combination drug containing two blood pressure medicines: Amlodipine, which relaxes your blood vessels, and Irbesartan, which blocks a chemical that tightens blood vessels. They work together to lower high blood pressure more effectively than either one alone.
Blocks L-type voltage-gated calcium channels in vascular smooth muscle, causing vasodilation and reduced peripheral vascular resistance, while simultaneously inhibiting angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone secretion to synergistically lower blood pressure.
High blood pressure (hypertension), especially when one medicine alone is not enough to bring your BP down to normal levels
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue with your normal schedule. Do not take two tablets at once to make up for the missed dose.
Avoid taking potassium supplements or potassium-rich salt substitutes without your doctor's knowledge, as Irbesartan can raise potassium levels. Be careful with painkillers like ibuprofen or diclofenac (commonly used in Nigeria) as they can reduce the blood pressure-lowering effect and affect your kidneys. Alcohol can make the blood pressure drop too much and worsen dizziness, so limit or avoid it.
Check your specific combination
Is it safe to take Amlodipine with your other drugs?
This drug is NOT safe during pregnancy. It can seriously harm or even kill your unborn baby, especially in the second and third trimesters. If you are pregnant, planning to become pregnant, or breastfeeding, tell your doctor immediately so they can switch you to a safer medicine.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it on windowsills or in your car. Keep the tablets in their original pack and away from children.
For information only: not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under, especially in Nigerian and West African pharmacies
Tap a brand for packaging, NAFDAC details and authenticity check
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.